Carcinostatic composition comprising indolquinolines

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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546 70, C07D47104, C07D22118, A61K 31435

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active

051283450

ABSTRACT:
Novel indoloquinoline compounds of formula (I), benzo(b)acridines of formula (II) and benzo(c)acridines of formula (III) have carcinostatic activities. The compounds, processes for preparing the compounds via nucleophilic aromatic substitution, and carcinostatic compositions containing the same are disclosed. ##STR1##

REFERENCES:
patent: 4826850 (1989-05-01), Yamato
Merck Manual, [Rahway, N.J. Merck and Co. 1987], pp. 2306 to 2309.
Yamato et al., J. Med. Chem., vol. 32, No. 6, pp. 1295-3000 (1989).
Atwell et al., J. Med. Chem., vol. 15 (6), pp. 611-615 (1972).
Cain et al., J. Med. Chem., vol. 17 (9), pp. 422-430 (1974).
Cain et al., J. Med. Chem., vol. 18 (11), pp. 3881-3884 (1979).
Van Echo et al., Canc. Res. 39, pp. 3881-3884 (Oct. 1979).
Dziewonski et al., Chem. Abs., vol. 59 (10), entry 11365d (1963).

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