Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1988-03-04
1990-04-03
Naff, David M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
424 9, 424 858, 4351728, 43524027, 435810, 436501, 436512, 436548, 436808, 436813, 530387, 530395, 935107, 935108, 935110, G01N 3353, G01N 33577, A61K 3900, C07K 1514
Patent
active
049140213
ABSTRACT:
Disclosed is a glycoprotein, carcinoma orosomucoid-related antigen, (CORA), which has a binding affinity for carcinoembryonic antigen (CEA). This glycoprotein is a marker for carcinoma, and can be characteried by having a molecular weight of about 46,000-50,000 daltons, an isoelectric point of about 3.0-3.5, a carbohydrate content of about 25-35% by weight, reactivity with antisera raised thereto, and substantially no reactivity with antisera raised to nonspecific cross-reacting antigen (NCA) or to CEA. Also disclosed are a hybridoma which produces a monoclonal antibody to CORA, the monoclonal antibody to CORA, and a device, kit, and method for detecting and monitoring carcinoma.
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Thomas Peter
Toth Carol A.
Hoffer Florina B.
Naff David M.
New England Deaconess Hospital Corporation
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