Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1989-05-12
1995-10-03
Scheiner, Toni R.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303888, 5303913, 435 723, C07K 1528, G01N 33574
Patent
active
054553326
ABSTRACT:
Monoclonal antibodies produced after immunization with a synthetic antigen bearing the structure Gal (beta 1-3) GalNac beta-glycosidically linked to a carrier moiety are useful as carcinoma markers. Radioimmunoimaging agents are described in which such antibodies are tagged with radiometals or radiohalogens. Radiolabeled monoclonal antibody 155H.7, elicited by this antigen, rapidly localizes and persists in tumor tissues, demonstrating its utility as a tumor imaging agent.
REFERENCES:
patent: 4798719 (1989-01-01), Ballou
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Georg F. Springer, et al., Breast Cancer Patient's Cell, Etc., Cancer 45: 2949-2954 (1980).
Irving L. Spar, An Immunologic Approach to Tumor Imaging, Seminars in Nuclear Medicine, 6: 4: 379-387 (Oct. 1976).
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Kohler, et al., Nature, vol. 256, (1975), pp. 495-497.
Hakomori, Monoclonal Antibodies Directed to Cell-Surface Carbohydrates in Monoclonal Antibodies and Functional Cell Lines 67-94 (Kennett, et al., eds. 1984).
Roitt et al., Immunology, The C. V. Mosby Company, St. Louis, 1985, pp. 8.2 and 8.3.
Hoppner et al., Vox Sang., vol. 48, pp. 246-253 (1985).
Studen, I., et al. Glycoconjugate J., vol. 2 (3-4), pp. 303-314 (1985). Abstract only.
Longenecker Bryan M.
MacLean Grant
Noujaim Antoine A.
Turner Connie J.
Willans David J.
Biomira, Inc.
Cooper Iver
Scheiner Toni R.
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