Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1998-12-15
1999-12-07
Saunders, David
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 21, 530350, A61K 3857, C07K 1481
Patent
active
059983736
ABSTRACT:
The invention provides a human carboxypeptidase inhibitor (CARIN) and polynucleotides which identify and encode CARIN. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of CARIN.
REFERENCES:
Normant, E. et al., "Carboxypeptidase A Isoforms Produced by Distinct Genes or Alternative Splicing in Brain and Other Extrapancreatic Tissues", J. Biol. Chem., 270: 20543-20549 (1995).
Normant, E. et al., "Purification, cDNA cloning, functional expression, and characterization of a 26-kDa endogenous mammalian carboxypeptidase inhibitor", Proc. Natl. Acad. Sci., 92: 12225-12229 (1995) (GI 1101779; GI 1101780).
Hatanaka, Y. et al., "Intracortical Regionality Represented by Specific Transcription for a Novel Protein, Latexin", Eur. J. Neurosci., 6: 973-982 (1994).
Jin, M. et al., (Direct Submission), GenBank Sequence Database (Accession D88769), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894 (GI 1669620; GI 1669621) (Nov. 14, 1996).
Hillier, L. et al., GenBank Accession #W04874 (1996).
Hillier, L. et al., GenBank Accession #W01258 (1996).
Alberts, B. et al., Molecular Biology of The Cell, Garland Publishing, Inc., New York, NY, pp. 189-191 (1983).
Hillier, L. et al.: "zv31f08.rl Soares ovary tumor NbHOT Homo sapiens cDNA clone 755271 5' similar to TR: E213399 Tissue Carboxypeptidase Inhibitor", EMBL Database, May 19, 1997. Gen Bank Accession No. AA422171.
Hillman Jennifer L.
Lal Preeti
Incyte Pharmaceuticals Inc.
Price Leanne C.
Saunders David
Tung Mary B
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