Carboxymethylmannoglucans and derivatives thereof

Details Carboxymethylmannoglucans and derivatives thereof Carboxymethylmannoglucans and derivatives thereof

1995-03-02

1996-10-22

Rollins, John W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 61, 514777, 5361231, 53612312, 536123, A61K 31725, A61K 3172, A61K 31715, A61K 4736

Patent

active

055676901

ABSTRACT:
A carboxymethylmannoglucan comprising tetrasaccharide units represented by the following general formula (I) and salt thereof. Further, the invention discloses a carboxymethylmannoglucan derivative and salt thereof produced by subjecting part or the whole of mannose of the tetrasaccharide units to ring opening and subjecting part or the whole of glucose which constitute the main chain but have no mannose as a branch ##STR1## wherein R.sup.1 to R.sup.12 each represent a hydrogen atom or a carboxymethyl group.
The compounds are useful as carrier for delaying the disappearance of a drug in the blood and for enhancing the organotropism of the drug for a carcinoma.

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Inoue et al (1983) Carbohydrate Resource, 123, 305-314.
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Derwent Publications Ltd., London, GB; AN 89-036770 & JP-A-63 310 827 (Sanwa Kagaku) (1988) (Abstract).
File Supplier PAJ/JPO & JP-A-1094949 (Yoshiaki Motozato) Apr. 13, 1989 (Abstract).

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