Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1981-07-13
1983-02-15
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
424324, A61K 31165, A61K 3119, A61K 31235
Patent
active
043741487
ABSTRACT:
A series of substituted phenylacetic acid compounds and their derivatives, including the pharmacologically acceptable base salts of said acids, have been found to be active as oral hypoglycemic agents. Preferred member compounds include 6-ethoxy-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid, 6-benzyloxy-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid, chroman-4-carboxylic acid, p-chlorophenylacetic acid, o-methylphenylacetic acid, o-methoxyphenylacetic acid, p-methoxyphenylacetic acid and .alpha.,.alpha.-di(4-methoxyphenyl)acetic acid. Synthetic routes leading to those member compounds which are novel per se are described in some detail.
REFERENCES:
patent: 3565904 (1971-02-01), Juby et al.
G. A. Stewart, "Pharmacological Studies on Oral Hypoglycemic Agents," Dtsch.-Eng. Med. Rundsch. (Anglo-German Medical Review), vol. 1, p. 334, (1962).
S. Ch. Lahiri et al., "Studies on Indan Acids as Potential Oral Hypoglycemic Agents," Journal of the Indian Chemical Society, vol. 53, p. 1041, (1976).
Knuth Charles J.
Pfizer Inc.
Richards Peter C.
Waddell Frederick E.
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