Carboxylic acid therapeutic agents

Details Carboxylic acid therapeutic agents Carboxylic acid therapeutic agents

1984-01-27

1985-07-23

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

560 56, 564180, C07C 334

Patent

active

045309191

ABSTRACT:
A series of substituted phenylacetic acid compounds and their derivatives, including the pharmacologically acceptable base salts of said acids, have been found to be active as oral hypoglycemic agents. Preferred member compounds include 6-ethoxy-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid, 6-benzyloxy-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid, chroman-4-carboxylic acid, p-chlorophenylacetic acid, o-methylphenylacetic acid, o-methoxyphenylacetic acid, p-methoxyphenylacetic acid and .alpha., .alpha.-di(4-methoxyphenyl)acetic acid. Synthetic routes leading to those member compounds which are novel per se are described in some detail.

REFERENCES:
patent: 4035512 (1977-07-01), Sugihara et al.
G. A. Stewart, "Pharmacological Studies on Oral Hypoglycemic Agents",Dtsch.-Eng. Med. Rundsch., (Anglo-German Medical Review), vol. 1, p. 334, (1962).
S. Ch. Lahiri et al., "Studies on Indan Acids as Potential Oral Hypoglycemic Agents", Journal of the Indian Chemical Society, vol. 53, p. 1041, (1976).

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