Carboxylic acid leukotriene B4 antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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549401, A61K 3135, C07D31138

Patent

active

052739996

ABSTRACT:
Compounds of the formula ##STR1## wherein X is O or CH.sub.2 ;

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patent: 4889871 (1989-12-01), Djuric et al.
patent: 4992576 (1991-02-01), Gapinski
Brown, F. J. et al.-Hydroxyacetophenone-Derived Antagonists of the Peptidoleukotrienes--J. Med. Chem. 1989, 32, 807-826.
Gapinski, D. M. et al.-Benzophenone Dicarboxylic Acid Antagonists of Leukotriene B.sub.4 --J. Med. Chem. 1990, 33, 2807-2873.
Konno, M. et al.-Synthesis and Structure-Activity Relationships of A Series of Substituted-Phenylpropionic Acids-Advances in Prostaglandin Thromboxane and Leukotriene Res. vol. 21, 411-413 (1990).
Communications--7-3-(4-acetyl-3-methoxy-2-prop ylphenoxy)propoxy-3,4-dihydro-8-propyl-2H-1-benzppyran-2-carboxylic acid-J. Med. Chem. 1989, vol. 32, No. 6, 1145-1147.

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