Carboxylic acid derivatives of N-substituted benzyl-1,2,5,6-tetr

Details Carboxylic acid derivatives of N-substituted benzyl-1,2,5,6-tetr Carboxylic acid derivatives of N-substituted benzyl-1,2,5,6-tetr

1979-11-07

1980-12-09

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424266, 544131, 546 6, 546316, 546322, A61K 31535, A61K 31455, C07D21178, C07D26530

Patent

active

042384885

ABSTRACT:
The invention concerns novel 1-benzyl-1,2,5,6-tetrahydropyridine-3-carboxylic acid derivatives of the formula: ##STR1## wherein R.sup.1 is hydroxy, amino, (1-4C)alkylamino, di-[(1-4C)alkyl]amino, benzyloxy optionally substituted by halogeno, or (1-6C)alkoxy optionally substituted by (1-4C)alkoxy, morpholino or di-[(1-4C)alkyl]amino; and benzene ring A bears one or two substituents selected from halogeno, (1-4C)alkyl, cyano, carboxamido, trifluoromethyl and hydroxy; and their pharmaceutically acceptable salts; together with pharmaceutical compositions thereof; and analogy processes for their manufacture.
The compounds of formula I are inhibitors of the aggregation of blood platelets and may be of application in the treatment or prophylaxis of thrombosis or occlusive vascular disease. A representative compound of the invention is 1-(2-chlorobenzyl)-1,2,5,6-tetrahydropyridine-3-carboxylic acid.

REFERENCES:
Stevens et al., J. Chem. Soc. Communications, (1975), p. 682.
Chem. Abstracts, (1958), 52, 9162 c-i.
Oediger et al., Annalen, (1972), 764, pp. 21-27.
Podesta et al., European J. Med. Chem., Chim. Therapeutica, 1974, 9, pp. 487-490.

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