Carboxylic acid derivatives as IP antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ortho-hydroxybenzoic acid or derivative doai

Reexamination Certificate

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Details

C514S163000, C514S166000, C562S430000, C562S433000, C562S434000, C562S435000, C562S437000

Reexamination Certificate

active

07056903

ABSTRACT:
This invention relates to compounds which are generally IP receptor antagonists and which are represented by Formula I:wherein:R1, R2, and R3are each independently in each occurrence aryl or heteroaryl;R4is —COOH or tetrazolyl;A, B, m, n, and r are as defined in the specification;or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and processes for their preparation.

REFERENCES:
patent: 5250517 (1993-10-01), Branca et al.
patent: 5610176 (1997-03-01), Horwell et al.
patent: 5981755 (1999-11-01), Horwell et al.
patent: 6221907 (2001-04-01), Bernard et al.
Hcaplus 100:210433.

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