Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-02-20
2007-02-20
McKenzie, Thomas (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S354000, C514S400000, C546S326000, C546S334000, C568S030000, C568S077000, C568S329000, C568S001000, C562S466000, C544S166000, C549S552000
Reexamination Certificate
active
10477106
ABSTRACT:
Compounds represented by formula (I), prodrugs thereof and salts thereof, and pharmaceutical compositions comprising the same as an active ingredient (wherein each symbol has the meaning as defined in the specification.).Because of having an EDG-1 agonism, the compounds represented by formula (I) are useful in preventing and/or treating peripheral arterial disease such as arteriosclerosis obliterans, thromboangiitis obliterans, Buerger's disease or diabetic neuropathy, sepsis, angiitis, nephritis, pneumonia, stroke, myocardial infarction, edematous state, atherosclerosis, varicosity such as hemorrhoid, anal fissure or fistula ani, dissecting aneurysm of the aorta, angina, DIC, pleuritis, congestive heart failure, multiple organ failure, bedsore, burn, chronic ulcerative colitis, Crohn's disease, heart transplantation, renal transplantation, dermal graft, liver transplantation, osteoporosis, pulmonary fibrosis, interstitial pneumonia, chronic hepatitis, liver cirrhosis, chronic renal failure, or glomerular sclerosis.
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D. Meyer Zu Heringdorf, et al., Stimulation of intracellular sphingosine-1-phosphate production by G-protein-coupled sphingosine-1-phosphate receptors, Eur. J. Pharmacol., Mar. 2001, vol. 414, pp. 145 to 154.
K. Sato, et al., Differential roles of Edg-1, and Edg-5, sphingosine 1-phosphate receptors, in the signaling pathways in c6 glioma cells, Brain. Res. Mol. Brain. Res., 2000, vol. 85, pp. 151 to 160.
Kohno Hiroshi
Seko Takuya
Takahashi Shinya
Terakado Masahiko
McKenzie Thomas
ONO Pharmaceutical Co., Ltd.
Robinson Binta
LandOfFree
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