Carboxylic acid derivatives

Details Carboxylic acid derivatives Carboxylic acid derivatives

1992-03-02

1995-03-21

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

549206, 549495, A61K 31555, C07D30752

Patent

active

053995562

ABSTRACT:
The invention relates to salts formed between ranitidine and a complex of zinc with a carboxylic acid selected from tartaric acid, citric acid and alkyl citric acids, and to solvates of such salts. The salts and solvates thereof are useful in the treatment of gastro-intestinal disorders, such as peptic ulcer disease and non-ulcer dyspepsia.

REFERENCES:
patent: 5008256 (1991-04-01), Clitherow
patent: 5041557 (1991-08-01), Vinas
Answer 1, Copyright 1991 American Chemical Society, d acc 100:96486v ab.
Current Trends Review, Drug Development Research 17:185-197 (1989): "Current Views of Zinc as a Gastrohepatic Protective Agent" by C. H. Cho, Dept. of Pharmacology, University of Hong Kong.
Drugs Exptl. Clin. Res. XV(2) 83-89 (1989), "Zinc Compounds, A New Treatment in Peptic Ulcer" by Escolar G. Bulbena O., Dept. of Pharmacology, Laboratorios Vinas S.A., Torrente Vidalet 29, 08012 Barcelona, Spain.

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