Carboxylic acid derivative and a pharmaceutical composition...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S342000, C514S345000, C546S269700, C546S271400, C546S301000

Reexamination Certificate

active

11178639

ABSTRACT:
A peroxisome proliferator activated receptor regulator containing a carboxylic acid derivative of formula (I)(wherein all symbols are as defined in the specification), a non-toxic acid thereof or a hydrate thereof as active ingredient.Because of having an effect of regulating PPAR, a compound of formula (I) is useful as a hypoglycemic agent, a hypolipidemic agent, a preventive and/or a remedy for diseases associating metabolic disorders (diabetes, obesity, syndrome X, hypercholesterolemia, hyperlipoproteinemia, etc.), hyperlipemia, atherosclerosis, hypertension, circulatory diseases, overeating, coronary heart diseases, etc., an HDL cholesterol-elevating agent, an LDL cholesterol and/or VLDL cholesterol-lowering agent and a drug for relief from risk factors of diseases or syndrome X.

REFERENCES:
patent: 5262540 (1993-11-01), Meanwell
patent: 0 402 246 (1990-12-01), None
patent: 0 930 299 (1999-07-01), None
Fayer et al., Pub Med Abstract, J. Clin. Pharmacol., 41 (3): 305-16, Mar. 2001.
Prandoni, et al. “The treatment of venous thromboembolic disorders: new challenges and opportunities,”Haematological/Journal of Hematology, vol. 88(05), pp. 610-612, May 2003.

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