Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2002-10-28
2004-02-10
Morris, Patricia L. (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S155000
Reexamination Certificate
active
06689791
ABSTRACT:
FIELD OF THE INVENTION
The present invention teaches compositions comprising carboxylated heterocyclic compounds and the synthesis of the same.
BACKGROUND
A variety of heterocyclic compounds have been described as having various pharmaceutical applications. However, the synthesis of such compounds, especially on a large scale, is often labor-intensive, expensive and time consuming. What is needed therefore, is a simplified and economical method for the synthesis and purification of heterocyclic compounds.
SUMMARY OF THE INVENTION
The present invention relates to compositions comprising carboxyflosequinan and the synthesis of the same.
In one embodiment, the present invention teaches a carboxylated heterocyclic compound corresponding to 3-carboxymethylsulfinyl-7-fluoro-1-methyl-4-quinolone (carboxyflosequinan) and derivatives thereof.
In one embodiment, the present invention teaches providing, 3-cyanomethylthio-7-fluoro-1-methyl-4-quinolone and a first acid followed by the reaction of said 3-cyanomethylthio-7-fluoro-1-methyl-4-quinolone and first acid under conditions such that 3-carboxymethylthio-7-fluoro-1-methyl-4-quinolone is produced.
In another embodiment the present invention further contemplates the reaction of 3-carboxymethylthio-7-fluoro-1-methyl-4-quinolone with a second acid and a peroxide under conditions such that 3-Carboxymethylsulfinyl-7-fluoro-1- methyl-4-quinolone is produced.
REFERENCES:
patent: 6307050 (2001-10-01), Kwiatowski et al.
Golinski Miroslaw
Kwiatkowski Stefan
Medlen & Carroll LLP
Morris Patricia L.
R. T. Alamo Ventures I, LLC
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