Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Enzymatic production of a protein or polypeptide
Patent
1994-04-12
1995-08-08
Lilling, Herbert J.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Enzymatic production of a protein or polypeptide
435106, 435117, 435121, 435123, 435128, 435134, 435198, C07K 506, C07K 510, C12P 2106, C12P 1304
Patent
active
054398061
ABSTRACT:
Carboxylates of polar, hydrophilic alcohols of the formula ##STR1## in which R is an unbranched or branched organic radical which contains, as polar members between aliphatic or araliphatic hydrocarbon bridges, ether oxygens, amine nitrogen groups or a mixture of ether and amine groups which can be incorporated into a cyclic structure, where the total length does not exceed 20 members and where, in the case of polyethylene glycol [(CH.sub.2 --CH.sub.2 --O).sub.n ], n indicates the number of the members and is defined as any integer, and R' is an aliphatic or araliphatic radical which has at least one functional group, are suitable as protective groups since they can be introduced selectively into functional groups of organic compounds and eliminated specifically by lipases.
REFERENCES:
patent: 4256836 (1981-03-01), Isowa et al.
patent: 4339534 (1982-07-01), Johansen et al.
patent: 4649156 (1987-03-01), Tanaka et al.
patent: 4668628 (1987-05-01), Dahod et al.
patent: 4841091 (1989-06-01), Tanaka et al.
patent: 4963492 (1990-10-01), Keller et al.
patent: 5037751 (1991-08-01), Bertola et al.
patent: 5089392 (1992-02-01), Miller et al.
patent: 5108916 (1992-04-01), Cobbs et al.
patent: 5159102 (1992-10-01), Tanaka et al.
patent: 5169780 (1992-12-01), Stirling et al.
Manfred Mutter, et al., "New Method of Polypeptide Synthesis," Angewandte Chemie, Int. Ed. Engl., 10:811-12 (1971).
Ernst Bayer, et al., "Synthese des Biologisch Aktriven Undecapeptids Substanz P nach der Flssig-Phasen-Methode," Chem. Ber. 107:1344-52 (1974).
Peter Braun, et al., "Selective Enzymatic Removal of Protecting Functions: Heptyl Esters as Carboxy Protecting Groups in Peptide Synthesis," Synlett (Letters) (1990) pp. 105-107.
Peter Braun, et al., "Selektive Enzymatische Schutzgruppenabspaltungen: Der n-Heptylester als Carboxylschutzgruppe in der Peptidsynthese," Liebigs Ann. Chem. (1991) pp. 165-170.
Rompps Chemielexikon, Franckh Fachlexikonverlag, Stuttgart, Germany, vol. 5 pp. 3744-3745.
G. M. Whitesides and C. H. Wong, "Enzyme in der Organischen Synthese," Angew. Chem. 97:617-638 (1985).
Chemical Abstracts vol. 95, No. 169102g (1981), "Water-soluble, esters: useful enzyme substrates for the synthesis of .beta.-lactam antibiotics,".
H. Kunz and M. Buchholz, "Das System 2-Halogenethylester/Cholinester als Zweistufen-Schutzgruppe fur die Carboxylfunktion von Aminosauren und Peptiden," Chem. Ber. 112:2145-2159 (1979).
M. Buchholz and H. Kunz, "Synthese von Glycopeptiden: Selektive C-terminale Deblockierung und Peptidkettenverlangerung an Glucosylserin-Derivaten," Liebigs Ann. Chem. (1983) pp. 1859-1885.
M. Mutter and Ernst Bayer, "The Liquid-Phase Method for Peptide Synthesis," The Peptides, vol. 2, Academic Press, New York (1979) pp. 286-332.
Braum Gnther
Braun Peter
Kunz Horst
Hoechst Aktiengesellschaft
Lilling Herbert J.
LandOfFree
Carboxylate protective groups, a process for their preparation, does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Carboxylate protective groups, a process for their preparation, , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Carboxylate protective groups, a process for their preparation, will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-970589