Carboxyl terminus analogs of .beta.-endorphin

Details Carboxyl terminus analogs of .beta.-endorphin Carboxyl terminus analogs of .beta.-endorphin

1979-12-10

1981-02-10

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C10352

Patent

active

042500877

ABSTRACT:
Novel carboxyl terminus analogs of .beta.-endorphin are described. The carboxyl terminus of such analogs is selected from lower alkyl amide, glycine, glycinamide, or polyglycine. These analogs exhibit either greater analgesic activity than the parent .beta.-endorphin and/or increased binding activity in an opiate binding assay.

REFERENCES:
patent: 4038222 (1977-07-01), Li
patent: 4116950 (1978-09-01), Li

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