Carboxyalkylureido cephalosporins

Details Carboxyalkylureido cephalosporins Carboxyalkylureido cephalosporins

1976-04-05

1978-06-27

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

2603322A, 560 34, 560123, 424246, 544 21, 544 26, 544 23, 560124, 560125, 560122, 560142, 560155, 560145, 560173L, 560 17, 560170, 560129, C07D50136

Patent

active

040976700

ABSTRACT:
Carboxyalkylureido cephalosporins of the formula ##STR1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, diphenyl-lower alkyl, tri(lower alkyl)silyl, trihaloethyl, a salt forming ion, or the group ##STR2## R.sub.1 is hydrogen or methoxy; A is straight or branched chain alkylene of 1 to 6 carbons; R.sub.2 is hydrogen, lower alkyl, phenyl, phenyl-lower alkyl, diphenyl-lower alkyl, alkali metal ion or alkaline earth metal ion; R.sub.3 is hydrogen or lower alkyl; R.sub.4 is hydrogen, lower alkyl, cycloalkyl, cycloalkenyl, cycloalkadienyl, phenyl, phenyl-lower alkyl, substituted phenyl, substituted phenyl-lower alkyl, or certain heterocyclic groups; R.sub.5 is hydrogen or lower alkyl; R.sub.6 is lower alkyl; and X is hydrogen, lower alkanoyloxy, ##STR3## or certain heterothio groups; are disclosed. These compounds are useful as antibacterial agents.

REFERENCES:
patent: 3708479 (1973-01-01), Welch et al.
patent: 3925368 (1975-12-01), Cooper et al.
patent: 3932392 (1976-01-01), Johnson et al.
patent: 3935204 (1976-01-01), Dahlen et al.

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