Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-12-19
1999-06-15
Dees, Jose' G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514386, 514389, 514392, 514275, 514396, 514402, 514269, 544300, 544302, 544309, 544311, 544314, 544319, 5483175, 5483195, 5483191, C07D23366, C07D23902, C07D23374, A61K 31415
Patent
active
059122617
ABSTRACT:
Carboxyalkyl heterocyclic derivatives, pharmaceutically acceptable salts thereof, and therapeutic agents containing said compounds as an effective component are useful pharmaceuticals for the treatment of diabetic complications such as diabetic neuropathy, diabetic cataracts and retinopathy, diabetic nephropathy, diabetic dermopathy, and other diabetic microangiopathy. The compounds of the present invention are represented by the following general formula (A): ##STR1## The compounds of the present invention exhibit excellent inhibitory action towards aldose reductase with a high enzyme selectivity. Accordingly, they are useful as drugs for the therapy and prevention of various types of diabetic complications without substantially inhibiting aldehyde reductase.
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Kotani Takayuki
Nagaki Yasuhiro
Okamoto Kaoru
Dees Jos,e G.
Nippon Zoki Pharmaceutical Co. Ltd.
Qazi Sabiha N.
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