Carboxyalkyl amino acid derivatives of various substituted proli

Details Carboxyalkyl amino acid derivatives of various substituted proli Carboxyalkyl amino acid derivatives of various substituted proli

1981-09-28

1984-07-31

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424177, 424274, 548533, C07C10352, A61K 3700, A61K 3140

Patent

active

044629435

ABSTRACT:
Carboxyalkyl dipeptides of the formula ##STR1## wherein R.sub.4 is a 3-, 4-, 5-, or 4,4-substituted proline are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity.

REFERENCES:
patent: 4105776 (1978-08-01), Ondetti et al.
patent: 4154935 (1979-05-01), Ondetti et al.
patent: 4217359 (1980-08-01), Krapcho

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