Carboxy terminal IL-6 muteins

Details Carboxy terminal IL-6 muteins Carboxy terminal IL-6 muteins

1994-04-22

1996-10-15

Walsh, Stephen G.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4352523, 4353201, 536 235, 530351, 424 852, C07K 1454, C12N 1524

Patent

active

055653367

ABSTRACT:
This invention relates to a Carboxy Terminal IL-6 Mutein with enhanced biological activity. The invention comprises a mutein of IL-6 having increased activity wherein the mutein has an amino acid substitution at, or corresponding to, amino acid location 171 or 175 of IL-6 having the wild-type sequence.

REFERENCES:
Leebeek et al., J. Biol. Chem. 267(21):14832-38 (1992).
Luttecken et al., FEBS 282(2): 265-267 (1991).
Feorello et al., Eur J Immunol 22:2609-15 (1992).
Yasueda et al., BBRC 187(1): 18-25 (1992).
Fontaine et al., Eur J Biochem 211:749-55 (1993).
Nishimura et al., FEBS 311(2):271-275 (1992).
Danley et al. FEBS 283(1):135-39 (1991).
Fantaine et al., Gene 104:227-34 (1991).
Nishimura et al., Eur J. Biochem 196(2):377-84 (1991).
Sugasarawa et al., Biotechnology 6, 895-902 (1988).
Lokker et al., EMBO J., 10 (8), 2125-2131 (1991).
Bazan, J. F. Immunol. Today 11, 350-354 (1990).
Brakenhoff et al., Journal of Immunology 143, 1175-1182 (1989).
Kruttgen, Al., et al., FEBS. Lett. 273, 95-98 (1990).
Snouwaert, J. N., et al., Journal of Biological Chemistry 266 (34) 23097-23102 (1991).

Affiliated with

Also associated with

Rating

Carboxy terminal IL-6 muteins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Carboxy terminal IL-6 muteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Carboxy terminal IL-6 muteins will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1245134