Carboxy terminal IL-6 muteins

Details Carboxy terminal IL-6 muteins Carboxy terminal IL-6 muteins

1992-07-23

1994-08-16

Draper, Garnette D.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Lymphokines, e.g., interferons, interlukins, etc.

930141, C07K 1300

Patent

active

053388330

ABSTRACT:
This invention relates to a Carboxy Terminal IL-6 Mutein with enhanced biological activity. The invention comprises a mutein of IL-6 having increased activity wherein the mutein has an amino acid substitution at, or corresponding to, amino acid location 171 or 175 of IL-6 having the wild-type sequence.

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Snouwaert, J. N., et al., Journal of Biological Chemistry 266 (34) 23097-23102 (1991).

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