Carboxy pyrrole, process of preparing and use as precursor

Details Carboxy pyrrole, process of preparing and use as precursor Carboxy pyrrole, process of preparing and use as precursor

2005-12-06

2005-12-06

Berch, Mark L. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C548S533000

Reexamination Certificate

active

06972331

ABSTRACT:
4-Oxo-4,5-dihydro-3H-pyrrolo[3,2-d] pyrimidine-7-carboxylic acid methyl ester and process for preparing are provided. The process for producing the 4-oxo-4,5-dihydro-3H-pyrrole[3,2-d]pyrimidine-7-carboxylic acid methyl ester comprises condensing 3-amino-1H-pyrrole-2,4-dicarboxylic acid dimethyl ester with formamidine acetate. The 4-oxo-4,5-dihydro-3H-pyrrole[3,2-d]pyrimidine- 7-carboxylic acid methyl ester is useful as a precusor for providing 9-deaza-hypoxanthine, a key intermediate for producing certain PNP inhibitors.

REFERENCES:
patent: WO-99/19338 (1999-04-01), None
patent: WO-00/61783 (2000-10-01), None
Mu III Lim, J. Org. Chem vol. 48, No. 6: Mar. 25, 1983 pp 780-788.
Furneaus et al. Improved Syntheses of 3H,5H-Pyrrolo [3,2-d] pyrimidines, J. Org Chem, 1999, 64, 8411-8412, American Chemical Society.
Elliott et al. A Short, Facile Synthesis of 2-Amino-1,5-dihydro-4H-pyrrolo[3,3,2-d]-pyrimidin-4-one (9-Deazaguanine), Tetrahedron Letters, vol. 37, No. 25, pp. 4339-4340, 1996 Copy right 1996 Elsevier Science Ltd.

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