(Carboxy-oxo-pyrrolidino)phenylalkenamides and esters thereof as

Details (Carboxy-oxo-pyrrolidino)phenylalkenamides and esters thereof as (Carboxy-oxo-pyrrolidino)phenylalkenamides and esters thereof as

1980-08-28

1981-10-20

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fungus, except allergen, or component thereof or substance...

26032641, 542420, A61K 3140, C07D207277

Patent

active

042961203

ABSTRACT:
Certain new propenamide and 2-butenamide compounds, having a (4-carboxy-2-oxo-pyrrolidino)phenyl substituent at the 3-position, and certain esters thereof, and their use for antagonizing the spasmogenic activity of slow-reacting substance of anaphylaxis (SRS-A) in a human subject. In particular, the compounds of the invention are useful for preventing and treating certain obstructive airways diseases, notably allergic bronchial asthma, allergic rhinitis and certain skin disorders, in human subjects.

REFERENCES:
patent: 3988371 (1976-10-01), Hansl

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