Carboxy containing ester prodrugs of corticosteroids

Details Carboxy containing ester prodrugs of corticosteroids Carboxy containing ester prodrugs of corticosteroids

1984-03-28

1986-05-13

Roberts, Elbert L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514179, 514180, 26023955D, 26039745, C07J 500

Patent

active

045887187

ABSTRACT:
A compound of the formula ##STR1## wherein St represents a corticosteroid moiety bonded to the carbonyl via the

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Anderson, B. D., et al., "Influence of Premicellar and Micellar Association on the Reactivity of Methylprednisolone 21-Hemiesters in Aqueous Solution," J. Pharm. Sci. 72(4), Apr. 1983, pp. 448-454.
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Garrett, E. R., "Prediction of Stability in Pharmaceutical Preparations X: Alkaline Hydrolysis of Hydrocortisone Hemmisuccinate," J. Pharm. Sci. 51(5), May 1962, pp. 445-450.
Garrett, E. R., "The Solvolysis of 21-Hydrocortisone Esters and Hemiesters," J. Med. Pharm. Chem. 5, 1962, pp. 112-133.
Kawamura, M., et al., "Pharmaceutical Studies on Water-soluble Corticosteroid Derivatives III. Stability of Hydrocortisone-21-Sulfobenzoates and 21-Sulfate in Solution," Yakugaku Zasshi 91, 1971, pp. 871-878.
Kawamura, M., et al., "Pharmaceutical Studies on Water-soluble Corticosteroid Derivatives. II. Stability of Hydrocortisone 21-Aminoalkylcarboxylates in Solution," Yakugaku Zasshi 91, 1971, pp. 863-870.
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