Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1983-11-22
1986-01-28
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
544295, 544364, 544372, 544373, A61K 31505, A61K 31495, C07D40314, C07D40306
Patent
active
045671800
ABSTRACT:
A carboximide derivative represented by the general formula: ##STR1## wherein X is ##STR2## Z is alkyl, aralkyl, cycloalkyl, cycloalkylalkyl, alkenyl or arylalkenyl, and Y is a substituted or unsubstituted pyridyl, pyrimidyl or phenyl group, and a pharmaceutically acceptable acid addition salt thereof. The carboximide derivative and acid addition salt are useful for treating diabetes and also for depressing the central nervous system. The carboximide derivative may be produced by reacting a sodium alkoxide represented by the general formula: ##STR3## wherein X and Y have the same meanings as defined above, with Z.Hal wherein Hal is a halogen and Z has the same meaning as defined above.
REFERENCES:
Lucas, Organic Chemistry, Sec. Ed., 1953, Amer. Book Co., N.Y., pp. 109-110, 212 and 220-221.
Hirose, et al., "Chemical Abstracts", vol. 98, 1982, col. 98:126160u.
"Chemical Abstracts", vol. 101, 1984, col. 101:110951x.
Akiyama Yasuhiro
Hirose Noriyasu
Kawashima Hidetoshi
Kuriyama Shizuo
Miyake Kazutoshi
Eisai Co. Ltd.
Hollrah Glennon H.
Turnipseed James H.
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