Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Patent
1989-12-22
1992-11-24
Page, Thurman M.
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
546176, 546330, 549 77, 549491, 558408, 558409, C07D24100, C07D21512, C07D33322, C07D25500
Patent
active
051663473
ABSTRACT:
Novel carboximidamide derivatives represented by the following formula (A) and acid adduct salts thereof are disclosed: ##STR1## wherein all the substituents have the same meanings as defined above. N-cyano-pyridinecarboximidate compounds represented by the following formula (II) which are the intermediates for preparing of N-cyano-N'-substituted-pyridinecarboximidamide derivatives wherein the substituent B in the above described formula (A) is pyridine is also disclosed: ##STR2## wherein all the substitutents have the same meanings as defined above. The process for preparing the compounds, the pharmaceutical agents comprising the compound having vasodilating effect, and the therapeutic method of dosing the compound on patients for therapy are also disclosed.
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Izawa Toshio
Kashiwabara Tomoko
Nakajima Shohachi
Ogawa Nobuyuki
Kirin Beer Kabushiki Kaisha
Kulkosky Peter F.
Page Thurman M.
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