Carboxamidine derivatives and hypoglycemical use

Details Carboxamidine derivatives and hypoglycemical use Carboxamidine derivatives and hypoglycemical use

1981-01-19

1982-06-08

Raymond, Richard

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

564238, 564239, 4242484, 564240, 548532, 42424858, 424250, 424251, 424267, 424270, 424272, 424273R, 424274, 424326, 544 3, 544 53, 544 59, 544 63, 544 88, 544162, 544165, 544224, 544242, 544335, 544402, 546231, 546246, 548146, 548214, 548215, 548240, 548300, 548356, 548569, 548531, A61K 31155, A61K 3154, C07C12900, C07D27910

Patent

active

043339298

ABSTRACT:
A compound of formula (II) or a pharmaceutically acceptable acid addition salt thereof ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are the same or different and each represents C.sub.1-6 alkyl; R.sup.5 represents hydrogen or C.sub.1-6 alkyl; R.sup.6 represents C.sub.1-6 alkyl, phenyl optionally substituted with up to 3 groups selected from halogen, C.sub.1-6 alkyl, and C.sub.1-6 alkoxy; or benzyl optionally substituted with up to 3 groups selected from halogen, C.sub.1-6 alkyl and C.sub.1-6 alkoxy; or R.sup.5 and R.sup.6 together represent the remaining members of a 5- or 6-membered ring optionally containing an oxygen, sulphur or additional nitrogen atom and being optionally substituted with C.sub.1-6 alkyl, carboxy or C.sub.1-6 alkoxycarbonyl; and R.sup.7 represents C.sub.1-6 alkyl, phenyl optionally substituted with up to 3 groups selected from halogen, C.sub.1-6 alkyl and C.sub.1-6 alkoxy; or benzyl optionally substituted with up to 3 groups selected from halogen, C.sub.1-6 alkyl and C.sub.1-6 alkoxy, has useful hypoglycaemic activity.

REFERENCES:
patent: 3261809 (1966-07-01), Sherr
Chem. Abst., 89, (Dec. 4, 1978), p. 51, No. 19105m.

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