Carboxamides useful as inhibitors of microsomal triglyceride...

Details Carboxamides useful as inhibitors of microsomal triglyceride... Carboxamides useful as inhibitors of microsomal triglyceride...

2005-04-12

2005-04-12

Ford, John M. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S389000, C544S400000, C544S392000, C544S166000, C544S383000, C544S360000, C514S255010, C514S255030, C514S319000, C514S278000, C514S255020, C514S253010, C546S205000, C546S019000

Reexamination Certificate

active

06878707

ABSTRACT:
Compounds of formula (I) wherein R2—C, R3—C, R4—C or R5—C may be replaced by N; and wherein n is 1, 2 or 3; R1is aryl, heteroaryl or (aryl or heteroaryl)-lower alkoxy; R2, R3, R4and R5are independently hydrogen, lower alkyl, lower alkoxy, halo, trifluoromethyl or cyano; R6is (i) or (ii) m is 1, 2 or 3; R7is hydrogen, lower alkyl (aryl or heteroaryl)-lower alkyl, lower alkoxy, (aryl or heteroaryl)-lower alkoxy, hydroxy, oxo, lower alkylenedioxy or lower alkanoyloxy; W is O, S or NR8; R8is —CORa, (iii), —COORd, —SO2Re, hydrogen, optionally substituted lower alkyl, aryl, heteroaryl or (aryl or heteroaryl)-lower alkyl; Ra, Rdand Reare independently optionally substituted lower alkyl, cycloalkyl, adamantyl, aryl, heteroaryl or (aryl or heteroaryl)-lower alkyl; Rband Rcare independently hydrogen, cycloalkyl, optionally substituted lower alkyl, aryl, heteroaryl or (aryl or heteroaryl) lower alkyl; or Rband Rctogether represent lower alkylene; and pharmaceutically acceptable salts thereof; and enantiomers thereof; which are useful as inhibitors of microsomal triglyceride transfer protein (MTP) and of apolipoprotein B (apoB) secretion.

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