Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Patent
1994-09-02
1996-09-24
Gerstl, Robert
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
544162, 544360, 546231, C07D21114, C07D26528, C07D40112, C07D41312
Patent
active
055592325
ABSTRACT:
The novel carboxamides of the formula ##STR1## wherein A, E, G, L, M, R and Q have the significance given in the description, as well as hydrates or solvates thereof inhibit thrombin-induced platelet aggregation and fibrinogen coagulation in plasma. They can be manufactured starting from the corresponding acid and the corresponding amine H.sub.2 NCH.sub.2 Q.
REFERENCES:
patent: 4227006 (1980-10-01), Okamoto et al.
patent: 4258192 (1981-03-01), Okamoto et al.
patent: 4879313 (1989-11-01), Tjoeng et al.
patent: 5037808 (1991-08-01), Tjoeng et al.
patent: 5053393 (1991-10-01), Tjoeng et al.
patent: 5260307 (1993-11-01), Ackerman et al.
patent: 5405854 (1995-04-01), Ackermann
J.Med.Chem. 33, 1990, 1406-1413.
BiochemJ. 55, 1955, 170-171.
J.Heterocycl. Chem. 23, 1986, 929-933.
J.Med.Chem. 1980, 23, 1293-1299, Vol. 12.
Pharmazie 39, 1984, 226-230.
Thrombosis & Haemotasis 67, 1992, 56-59.
Drugs of the Future 17, 1992, 1087-90.
Ackermann Jean
Banner David
Gubernator Klaus
Hilpert Kurt
Schmid G erard
Epstein William H.
Gerstl Robert
Gould George M.
Hoffmann-La Roche Inc.
Pokras Bruce A.
LandOfFree
Carboxamides does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Carboxamides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Carboxamides will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1929471