Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...
Patent
1995-04-13
1998-04-14
Kight, John
Organic compounds -- part of the class 532-570 series
Organic compounds
Unsubstituted hydrocarbyl chain between the ring and the -c-...
534 10, 534 16, 424 153, 424 165, 424 9363, C07D25502, C07F 1300, A61K 5110, A61K 4900
Patent
active
057393230
ABSTRACT:
A group of functionalized polyaminocarboxamide modified chelators, such as 1,4 7,10-tetraaza-1-N-(1-carboxy-3-(4-aminophenyl)propyl)-7-N-(1-carboxymethyl )bis-4,10-N,N-(carboxamidomethyl)cyclododecane and 1,4 7,10-tetraaza-1-N-(1-carboxy-3-(4-aminophenyl)propyl)bis-4,7-N,N-(1-carbox ymethyl)-10-N-(carboxamidomethyl)cyclododecane are disclosed. These modified chelators are capable of forming complexes with rare earth-type metal ions. When the complexes are covalently attached to an antibody or antibody fragment, they can be used in therapeutic and diagnostic applications.
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Fordyce William A.
Kruper, Jr. William J.
Sherry A. Dean
Kelley Lara C.
Kight John
Kimble Karen L.
The Dow Chemical Company
Ulmer Duane C.
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