Carboxamide derivatives

Details Carboxamide derivatives Carboxamide derivatives

1989-12-29

1991-09-17

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548251, 548253, 548467, 548468, 548484, 548494, 548359, 548372, 546193, 546194, 546201, 544124, 544143, 544365, 544373, 544353, C07D20904, C07D25704, C07D21168, C07D41312

Patent

active

050496794

ABSTRACT:
This invention provides a series of novel heterocyclic amides of formula I in which the group >X--Y--Z< is selected from >C.dbd.CH--N<, >C.dbd.N--N<, >N--(CH.sub.2)--N<, >CH--CH.sub.2 --N< and <N--N.dbd.C< and the other radicals have the meanings defined in the following specification.
The compounds of formula I are leukotriene antagonists. The invention also provides pharmaceutically acceptable salts of the formula I compounds; pharmaceutical compositions containing the formula I compounds, or their salts, for use in the treatment of, for example, allergic or inflammatory diseases, or endotoxic or traumatic shock conditions; and processes for the manufacture of the formula I compounds, as well as intermediates for use in such manufacture.

REFERENCES:
Brown et al., Chem. Abstracts, vol. 108, No. 21; 186571p (1988).

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