Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1989-12-29
1991-09-17
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514406, 548371, 548372, A61K 31415, C07D23154
Patent
active
050495763
ABSTRACT:
This invention provides a series of novel heterocyclic amides of formula I in which the group >X--Y--Z< is selected from >C.dbd.CH--N<, >C.dbd.N--N<, >N--(CH.sub.2)--N<, >CH--CH.sub.2 --N< and >N--N.dbd.C< and the other radicals have the meanings defined in the following specification.
The compounds of formula I are leukotriene antagonists. The invention also provides pharmaceutically acceptable salts of the formula I compounds; pharmaceutical compositions containing the formula I compounds, or their salts, for use in the treatment of, for example, allergic or inflammatory diseases, or endotoxic or traumatic shock conditions; and processes for the manufacture of the formula I compounds, as well as intermediates for use in such manufacture.
REFERENCES:
Hannig et al., "Zur Kenntnis Einiger Derivate des 1-Benzyl-6-Aminoindazols", Pharmazie 29, H 10-11, 1974, pp. 685-686.
Bernstein Peter R.
Brown Frederick J.
Matassa Victor G.
Yee Ying K.
ICI Americas Inc.
Ivy C. Warren
Jackson Thomas E.
Miano Rosemary M.
Northington-Davis Zinna
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