Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-11-03
1996-11-19
Chang, Celia
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514318, 514326, 514329, 546 19, 546189, 546193, 546208, 546210, 546224, C07D21126, C07D40104, A61K 31445
Patent
active
055763332
ABSTRACT:
The present invention concerns novel carboxamide derivatives of formula I, ##STR1## wherein R.sup.1, R.sup.2, J, m, and M have any of the values defined in the specification, which antagonize the pharmacological actions of one of the endogenous neuropeptide tachykinins at the neurokinin 2 (NK2) receptor, making them useful whenever such antagonism is desired, such as in the treatment of asthma and related conditions. The invention also provides pharmaceutical compositions containing the novel carboxamide derivatives for use in such treatment, methods for their use, and processes and intermediates for the manufacture of the novel carboxamide derivatives.
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Edmonds-Alt et al "Preparation of 1(alkyl or acyl) 4-(3aryl-4-aminobutyl) piperidine as substance P receptor binding inhibitors" CA 118:124404j (1993).
Goulaouic et al "Preparation of 1-aralkyl-3 ayl-piperidine alkyl piperidine and analog as substance P and neurokinin antagonists" CA 118:124405K (1993).
Fujii et al "Effects of Actinomycin D on airway constriction induced by Tachykinins" BA 91:124844 (1991).
Chang Celia
Harris Robert J.
Jackson Thomas E.
Zeneca Limited
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