Carboxamide compounds as SRS-A antagonists

Details Carboxamide compounds as SRS-A antagonists Carboxamide compounds as SRS-A antagonists

1981-08-13

1982-05-25

Breitenstein, G. T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

424319, 560 37, 562442, A61K 3124, C07C101447, C07C101453

Patent

active

043316832

ABSTRACT:
The compounds of the invention are certain new propenamides and 2-butenamides having a (carboxyalkanamido)phenyl or a (carboxyalkenamido)phenyl group at the 3-position, and certain esters thereof, and certain cyclopropanecarboxamide compounds having a (carboxyalkanamido)phenyl group or a (carboxyalkenamido)phenyl group at the 2-position, and certain esters thereof. The compounds are useful for antagonizing the spasmogenic activity of slow-reacting substance of anaphylaxis (SRS-A) in a human subject. In particular, the compounds of the invention are useful for preventing and treating certain obstructive airways diseases, notably allergic bronchial asthma, allergic rhinitis and certain skin disorders, in human subjects.

REFERENCES:
patent: 3966965 (1976-06-01), Sellstedt et al.

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