Carbostyril derivatives and process for preparing the same

Details Carbostyril derivatives and process for preparing the same Carbostyril derivatives and process for preparing the same

1978-08-10

1980-09-16

Randolph, John D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

42424856, 424250, 424258, 544363, 546157, 546158, C07D21526, C07D21532

Patent

active

042231370

ABSTRACT:
Carbostyril derivative represented by the formula (I): ##STR1## wherein R.sup.1 and R.sup.2, which may be the same or different, each represents a hydrogen atom, a cycloalkylcarbonyl group, a cycloalkylalkanoyl group, a benzoyl group, an alkanoyl group or a phenylalkylcarbonyl group; R.sup.4 represents a hydrogen atom or an alkyl group, R.sup.5 and R.sup.6, which may be the same or different, each represents a hydrogen atom, an alkyl group, a cycloalkyl group, or a phenylalkyl group, or R.sup.5 and R.sup.6 may, when taken together with the nitrogen atom to which they are attached, form a 5- or 6-membered substituted or unsubstituted heterocyclic ring containing 1 or 2 nitrogen or oxygen atoms as hetero atoms; and the ring A has a partial structure: ##STR2## wherein R.sup.3 represents a hydrogen atom, a cycloalkylcarbonyl group, a cycloalkylalkanoyl group, a benzoyl group, an alkanoyl group or a phenylalkylcarbonyl group, with the proviso that at least one of R.sup.1, R.sup.2 and R.sup.3 when R.sub.3 is present, or at least one of R.sub.1 and R.sub.2 when R.sub.3 is absent, represents a cycloalkylcarbonyl group, a cycloalkylalkanoyl group, a benzoyl group, an alkanoyl group or a phenylalkylcarbonyl group; the pharmaceutically acceptable acid addition salts of the above carbostyril compounds represented by the formula (I), and processes for preparing the above carbostyril compounds represented by the formula (I).

REFERENCES:
patent: 3975391 (1976-08-01), Nakagawa et al.
patent: 3994901 (1976-11-01), Nakagawa et al.
patent: 4022776 (1977-05-01), Nakagawa et al.
patent: 4022784 (1977-05-01), Nakagawa et al.
patent: 4026897 (1977-05-01), Nakagawa et al.
patent: 4072683 (1978-02-01), Nakagawa et al.

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