Carbostyril derivatives and pharmaceutical composition containin

Details Carbostyril derivatives and pharmaceutical composition containin Carbostyril derivatives and pharmaceutical composition containin

1991-08-06

1994-04-05

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514278, 544 586, 544128, 544237, 544238, 544284, 544333, 544353, 544363, 546 16, 546157, 546158, 546148, A61K 3147, C07D40112

Patent

active

053005139

ABSTRACT:
Novel carbostyril derivatives of the formula: ##STR1## wherein X is 0 or S; Y is H or alkyl; R.sup.A is a group of the ##STR2## {wherein n is 1 or 2, A is alkylene, R.sup.1 is benzoyl having optionally 1-3 substituents, R.sup.2A is ##STR3## is (i) alkoxy, (ii) substituted or unsubstituted 5- or 6-membered heterocylic group, (iii) alkenylthio, (iv) pyrrolidinyl-alkyl--S--, (v) pyrrolidinyl-alkyl--SO--, (vi) pyrrolidinyl-alkyl--SO.sub.2 --, (vii) --O--B--NR.sup.4 R.sup.5 [B is alkylene having optionally OH, R.sup.4 is H, R.sup.5 is tricyclo[3.3.1.1]decanyl, tricyclo[3.3.1.1]decanylalkyl, etc., or R.sup.4 and R.sup.5 may together form a group of ##STR4## (R.sup.6 is substituted or unsubstituted amino)] or (viii) substituted alkoxy; m is 1 to 3]}, which have excellent vasopressin antagonistic activities and are useful as vasodilator, hypotensive agent, water diuretics, platelet agglutination inhibitor, and a vasopressin antagonistic composition containing the compound as the active ingredient.

REFERENCES:
Chemical Abstracts, vol. 114, No. 1, Jan. 7, 1991 (Abstract No. 6 302u).
Chemical Abstracts, vol. 81, No. 13, Sep. 30, 1974 (Abstract No. 77 786r).

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