Carbostyril derivatives, and antihistaminic agents containing th

Details Carbostyril derivatives, and antihistaminic agents containing th Carbostyril derivatives, and antihistaminic agents containing th

1982-03-12

1984-11-13

Coughlan, Jr., Paul M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546157, 546158, A61K 3147, C07D21522, C07D21526

Patent

active

044825609

ABSTRACT:
Novel carbostyril derivatives and their salts having antihistaminic effects and are useful as antihistaminic agents, represented by the general formula (1), ##STR1## wherein R.sup.1 is a hydrogen atom, a lower alkenyl group, a lower alkynyl group or a lower alkyl group which may have phenyl group(s) as the substituted group(s); R.sup.2 is a hydrogen atom, a lower alkyl group or a phenyl group; R.sup.3 is a lower alkyl group having phenyl group(s) as the substituted group(s), or a phenyl group which may have 1 to 3 substituted groups selected from the group consisting of halogen atoms, lower alkyl groups and lower alkoxy groups; R.sup.4 is a hydrogen atom, a hydroxyl group or a lower alkanoyl group; X is a halogen atom; Y is a lower alkylene group which may have hydroxyl group(s) as the substituent(s); n is 0, 1 or 2; the carbon-carbon bond between 3- and 4-positions in the carbostyril skeleton is a single or double bond; provided that when R.sup.3 is a lower alkyl group having phenyl group(s) as the substituted group(s), then R.sup.4 should be neither a hydroxyl group nor a lower alkanoyl group.

REFERENCES:
patent: 3629266 (1971-12-01), Havera
patent: 3910924 (1975-10-01), Tamura et al.
patent: 3994900 (1976-11-01), Krapcho et al.
patent: 4147869 (1979-04-01), Nakagawa et al.
patent: 4210753 (1980-07-01), Tominaga et al.
patent: 4256890 (1981-03-01), Nakagawa et al.
patent: 4330549 (1982-05-01), Friebe et al.

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