Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1993-06-22
1995-10-10
Datlow, Philip I.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514218, 514253, 514312, 540575, 540597, 544363, 546157, 546158, C07D40106, A61K 3147
Patent
active
054570999
ABSTRACT:
1. A compound of the formula: ##STR1## wherein the symbol of a solid line with a broken line means a single bond or a double bond,
R and R' are independently selected from the group consisting of hydrogen atom, halogen atom, lower alkyl, nitro, unsubstituted amino and substituted amino,
A and B are independently selected from the group consisting of hydrogen atom, lower alkyl optionally substituted with a lower cycloalkyl, aryl optionally substituted with one or more halogen atoms and the group: -Y-R.sup.2
wherein Y is lower alkylene and R.sup.2 is the group: ##STR2## wherein m is integer of 1 to 3, n is 0 or 1, Z is >N-, >CH-- or >C=, R.sup.3 is diaryl (lower) alkyl optionally substituted with one or more halogen atoms or is condensed heterocyclic group optionally substituted with oxo, with the proviso that
(a) at least one of A and B is the group -Y-R.sup.2 and
(b) when A is hydrogen atom and B is the group -Y-R.sup.2, then Z is >CH-- or >C= if R.sup.3 is condensed heterocyclic group optionally substituted with oxo and n is O
or a pharmaceutically acceptable salt thereof. The compounds of the above formula have antiallergic activity.
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Furukawa Masumi
Kakita Takao
Masai Emi
Nakatsugi Seiichi
Shogaki Takeshi
Datlow Philip I.
Sawai Pharmaceutical Co., Ltd.
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