Carbostyril derivative

Details Carbostyril derivative Carbostyril derivative

1983-09-02

1986-01-14

Lesmes, George F.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546155, 546157, 546158, C07D21522, A61K 3147

Patent

active

045646198

ABSTRACT:
Carbostyril derivative or a pharmaceutically acceptable acid addition salt thereof, having excellent platelate aggregation inhibitory effect, calcium antagonism, hypotensive effect and phosphodiesterase inhibitory effect are useful as prophylactic or treating agents for thrombosis, circulation improving agents for coronary blood flow such as coronary vasodilators, hypotensive agents and phosphodiesterase inhibitors. Furthermore, the carbostyril derivatives are weak in heart rate increasing activity and also in cardiac muscle contraction increasing activity, and the carbostyril derivatives are useful agents for curing and treating heart diseases such as cardiac angina and myocardial infarction caused by hypercoagulability of the platelets. Processes are disclosed for preparation of the carbostyril derivatives.

REFERENCES:
patent: 4044141 (1977-08-01), Bossert et al.
patent: 4081447 (1978-03-01), Prasad et al.
patent: 4288452 (1981-09-01), Sombroek et al.
patent: 4298739 (1981-11-01), Nishi et al.
patent: 4450165 (1984-05-01), Araki et al.
patent: 4482560 (1984-11-01), Banno et al.
Nishi, T. et al., Chem. Abstracts 90:38801h (JA 78/90270).
Nishi, T. et al., Chem. Abstracts 90:38802j (JA 78/87363).

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