Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2008-09-19
2011-12-06
Rao, Deepak (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S312000, C514S318000, C546S146000, C546S156000, C546S194000
Reexamination Certificate
active
08071615
ABSTRACT:
This invention comprises the novel compounds of formula (I)wherein n, m, t, R1, R2, R3, R4, R5, L, Q, X, Y andhave defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
REFERENCES:
patent: 3331843 (1967-07-01), Tomcufcik et al.
patent: 3966743 (1976-06-01), Berger et al.
patent: 4049811 (1977-09-01), Berger et al.
patent: 4348401 (1982-09-01), Friebe et al.
patent: 4455422 (1984-06-01), Banno et al.
patent: 5025012 (1991-06-01), Miura et al.
patent: 5147876 (1992-09-01), Mizuchi et al.
patent: 5338738 (1994-08-01), Matson et al.
patent: 5342846 (1994-08-01), Singh et al.
patent: 5780454 (1998-07-01), Adams et al.
patent: 5789412 (1998-08-01), Halazy et al.
patent: 5952349 (1999-09-01), Asberom et al.
patent: 6066730 (2000-05-01), Adams et al.
patent: 6083903 (2000-07-01), Adams et al.
patent: 6294538 (2001-09-01), Mylari
patent: 6518283 (2003-02-01), Langham et al.
patent: 7205304 (2007-04-01), Van Emelen et al.
patent: 7446109 (2008-11-01), Van Emelen et al.
patent: 7501417 (2009-03-01), Van Emelen et al.
patent: 7541369 (2009-06-01), Angibaud et al.
patent: 7592450 (2009-09-01), Van Emelen
patent: 7615553 (2009-11-01), Van Emelen et al.
patent: 7704998 (2010-04-01), Van Emelen et al.
patent: 7709487 (2010-05-01), Van Emelen et al.
patent: 7767679 (2010-08-01), Van Emelen et al.
patent: 7816363 (2010-10-01), Angibaud et al.
patent: 7834011 (2010-11-01), Roux et al.
patent: 7834025 (2010-11-01), Angibaud et al.
patent: 7884105 (2011-02-01), Van Emelen
patent: 7888360 (2011-02-01), Angibaud et al.
patent: 2002/0032195 (2002-03-01), Breitfelder et al.
patent: 2004/0248897 (2004-12-01), Priepke et al.
patent: 2005/0080258 (2005-04-01), Davis et al.
patent: 2005/0096468 (2005-05-01), Van Emelen et al.
patent: 2005/0107384 (2005-05-01), Angibaud et al.
patent: 2005/0171347 (2005-08-01), Van Emelen et al.
patent: 2005/0197336 (2005-09-01), Anandan et al.
patent: 2005/0222414 (2005-10-01), Van Emelen et al.
patent: 2007/0135424 (2007-06-01), Van Brandt et al.
patent: 2008/0132459 (2008-06-01), Moradei et al.
patent: 2008/0255140 (2008-10-01), Van Emelen
patent: 2009/0005393 (2009-01-01), Angibaud et al.
patent: 2009/0018152 (2009-01-01), Angibaud et al.
patent: 2009/0018153 (2009-01-01), Angibaud et al.
patent: 2009/0023726 (2009-01-01), Roux et al.
patent: 2009/0036463 (2009-02-01), Angibaud et al.
patent: 2009/0124646 (2009-05-01), Verdonck et al.
patent: 2009/0143401 (2009-06-01), Marconnet-Decrane et al.
patent: 2009/0170836 (2009-07-01), Angibaud et al.
patent: 2009/0170881 (2009-07-01), Angibaud et al.
patent: 2009/0221580 (2009-09-01), Angibaud et al.
patent: 2009/0227558 (2009-09-01), Angibaud et al.
patent: 2009/0270419 (2009-10-01), Arts et al.
patent: 2010/0009988 (2010-01-01), Van Emelen
patent: 2010/0010004 (2010-01-01), Van Emelen et al.
patent: 2010/0048588 (2010-02-01), Van Emelen et al.
patent: 2010/0160321 (2010-06-01), Holte et al.
patent: 2010/0234353 (2010-09-01), Van Emelen et al.
patent: 2010/0240639 (2010-09-01), Van Emelen et al.
patent: 2 491 131 (2004-01-01), None
patent: 2 518 950 (2005-02-01), None
patent: 042 28 792 (1994-03-01), None
patent: 102 33 412 (2004-02-01), None
patent: 0 076 530 (1983-04-01), None
patent: 0 188 094 (1992-03-01), None
patent: 0 827 742 (1998-03-01), None
patent: 1 312 609 (2005-12-01), None
patent: 1 501 508 (2007-02-01), None
patent: 1 581 484 (2007-07-01), None
patent: 1 485 354 (2008-05-01), None
patent: 1 485 365 (2008-05-01), None
patent: 1 485 348 (2008-06-01), None
patent: 1 485 378 (2008-06-01), None
patent: 1 492 534 (2008-06-01), None
patent: 1 627 880 (2008-10-01), None
patent: 1 485 364 (2009-03-01), None
patent: 1 485 370 (2009-03-01), None
patent: 1 611 088 (2009-06-01), None
patent: 1 590 340 (2010-04-01), None
patent: 1 673 349 (2010-06-01), None
patent: 1 485 099 (2010-07-01), None
patent: 2 104 509 (1997-10-01), None
patent: 0 901 749 (1962-07-01), None
patent: 1 345 872 (1974-02-01), None
patent: WO-94/25437 (1994-11-01), None
patent: WO-96/13266 (1996-05-01), None
patent: WO-97/23216 (1997-07-01), None
patent: WO-98/55449 (1998-12-01), None
patent: WO-00/26203 (2000-05-01), None
patent: WO-0035855 (2000-06-01), None
patent: WO-00/52001 (2000-09-01), None
patent: WO-00/71516 (2000-11-01), None
patent: WO 01/38322 (2001-05-01), None
patent: WO 01/70675 (2001-09-01), None
patent: WO-02/00651 (2002-01-01), None
patent: WO-02/18335 (2002-03-01), None
patent: WO-02/42271 (2002-05-01), None
patent: WO 2006/122926 (2002-11-01), None
patent: WO-03/000653 (2003-01-01), None
patent: WO-03/011851 (2003-02-01), None
patent: WO-03/035855 (2003-05-01), None
patent: WO-03/066579 (2003-08-01), None
patent: WO 03/075929 (2003-09-01), None
patent: WO 03/076395 (2003-09-01), None
patent: WO 03/076400 (2003-09-01), None
patent: WO 03/076401 (2003-09-01), None
patent: WO 03/076421 (2003-09-01), None
patent: WO-03/076422 (2003-09-01), None
patent: WO 03/076430 (2003-09-01), None
patent: WO 03/076438 (2003-09-01), None
patent: WO-03/082288 (2003-10-01), None
patent: WO-03/087057 (2003-10-01), None
patent: WO-03/092686 (2003-11-01), None
patent: WO-2004/009536 (2004-01-01), None
patent: WO-2004/013130 (2004-02-01), None
patent: WO-2004/056748 (2004-07-01), None
patent: WO-2004/063146 (2004-07-01), None
patent: WO-2004/063169 (2004-07-01), None
patent: WO-2004/065354 (2004-08-01), None
patent: WO-2004/069803 (2004-08-01), None
patent: WO-2004/069823 (2004-08-01), None
patent: WO-2004/071400 (2004-08-01), None
patent: WO-2004/072047 (2004-08-01), None
patent: WO-2004/082638 (2004-09-01), None
patent: WO-2004/087693 (2004-10-01), None
patent: WO-2004/092115 (2004-10-01), None
patent: WO-2005/028447 (2005-03-01), None
patent: WO-2005/030704 (2005-04-01), None
patent: WO-2005/030705 (2005-04-01), None
patent: WO-2005/040101 (2005-05-01), None
patent: WO-2005/040161 (2005-05-01), None
patent: WO-2005/075469 (2005-08-01), None
patent: WO-2005/086898 (2005-09-01), None
patent: WO-2005/092899 (2005-10-01), None
patent: WO 2006/010749 (2006-02-01), None
patent: WO-2006/010750 (2006-02-01), None
patent: WO 2006/136553 (2006-12-01), None
patent: WO-2007/016532 (2007-02-01), None
patent: WO 2007/048767 (2007-05-01), None
patent: WO 2007/082873 (2007-07-01), None
patent: WO 2007/082874 (2007-07-01), None
patent: WO 2007/082876 (2007-07-01), None
patent: WO 2007/082878 (2007-07-01), None
patent: WO 2007/082880 (2007-07-01), None
patent: WO 2007/082882 (2007-07-01), None
patent: WO 2008/031820 (2008-03-01), None
Archibald et al., “Benzamidopiperidines. 3. Carbocyclic Derivatives Related to Indoramin,”Journal of Medicinal Chemistry, 1974; 17(7):739-744.
Finnin et al., “Structures of a Histone Deacetylase Homologue Bound to the TSA and SAHA Inhibitors,”Nature, 1999; 401:188-193.
Glaser et al., “HDAC Inhibitors: Clinical Update and Mechanism-based Potential,”Biochemical Pharmacology, 2007; 74(5):659-671.
Gorrod et al., “The Metabolism ofN-Ethyl-N-methylaniline by Rabbit Liver Microsomes: The Measurement of Metabolites by Gas—Liquid Chromatography,”Xenobiotica, 1975; 5(8):453-463.
Irikura et al., “Absorption, Excretion, and Metabolism of 1-(p-aminobenzoyl)-4-(3,4,5-trimethoxybenzamido)piperidine (KU-55),” Oyo Yakuri (1973), 7(7), 985-990.
Marks et al, “Histone deacetylases and Cancer: Causes and Therapies,”Nature Reviews: Cancer, 2001; 1(3):194-202.
Mosmann et al., “Rapid Colorimetric Assay for Cellular Growth and Survival: Application to Proliferation and Cytotoxicity Assays,”Journal of Immunological Methods, 1983; 65:55-63.
Simone et al., “Oncology: Introduction,”Cecil Textbook of Medicine, 20thEdition, 1996; 1:1004-1010.
Sternson et al., “Synthesis of 7200 Small Molecules Based on a Substructural Analysis of the Histone Deacetylase Inhibitors Trichostatin and Trapoxin,”Organic Letters, 2001; 3(26):4239-4242.
In the U.S. Patent and Trademark Office, Non-Final Office Action in re: U.S. Appl. No. 10/507,159 dated Jun. 25, 2
Backx Leo Jacobus Jozef
Van Brandt Sven Franciscus Anna
Van Emelen Kristof
Verdonck Marc Gustaaf Celine
Janssen Pharmaceutica N.V.
Patton & Boggs LLP
Rao Deepak
LandOfFree
Carbonylamino-derivatives as novel inhibitors of histone... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Carbonylamino-derivatives as novel inhibitors of histone..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Carbonylamino-derivatives as novel inhibitors of histone... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4315780