Carbonyl reductase, method for producing said enzyme, DNA...

Details Carbonyl reductase, method for producing said enzyme, DNA... Carbonyl reductase, method for producing said enzyme, DNA...

2005-11-29

2005-11-29

Rao, Manjunath (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Oxidoreductase

C435S025000, C435S069100, C435S252300, C536S023200

Reexamination Certificate

active

06969600

ABSTRACT:
A novel carbonyl reductase useful for producing alcohol, particularly derivatives of (S)-4-halo-3-hydroxybutyrate ester, is provided. A novel carbonyl reductase derived fromKluyveromyces aestuariiand the nucleic acid encoding the enzyme are provided. The carbonyl reductase has excellent reductase activity and stereoselectivity. The carbonyl reductase reduces ketone to produce alcohol. It can be particularly advantageous when used in industrial production of (S)-4-halo-3-hydroxybutyrate ester.

REFERENCES:
patent: 0 927 755 (1999-07-01), None
patent: 0 967 271 (1999-12-01), None
Kita et al., “Cloning, Overexpression, and Mutagenesis of the . . . ,” Applied and Environmental Microbiology, vol. 65, No. 12, pp. 5207-5211, 1999.
Bradshaw et al., “APseudomonassp. Alcohol Dehydrogenase with Broad . . . ,” J. Org. Chem., vol. 57, pp. 1526-1532, 1992.
Shieh et al., “Stereochemical Control of Yeast . . . ,” J. Am. Chem. Soc., vol. 107, pp. 2993-2994, 1985.
Patel et al., “Stereoselective reduction of . . . ,” Enzyme Microb. Technol., vol. 14, pp. 731-738, 1992.
Peters et al. “A novel NADH-dependent carbonyl reductase with an extremely broad substrate range fromCandidan parapsilosis: purification and characterization,”Enzyme Microb. Technol., 15(11):pp. 950-958.

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