Carbonyl arylations and vinylations using transition metal catal

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters

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560 12, 568312, 568317, 558371, C07C25507, C07C30316, C07C 4537

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active

060720735

ABSTRACT:
The invention is directed to a process for preparing an alpha-arylated or vinylated carbonyl-containing compounds, comprising reacting a compound having a carbonyl group with an arylating or vinylating compound in the presence of a base and a transition metal catalyst. The transition metal catalyst has the formula X.sub.n M(ER.sub.1-4).sub.m, wherein X is an optional ligand, M is a group 8 transition metal, E is an element bearing a nonbonding electron pair when E is not bonded to the metal, and R is a substituent bonded to E through a carbon, nitrogen, oxygen, or sulfur atom, with the proviso that R.sub.3 cannot contain 3 aryl groups, n is an integer from 0 to 4, and m is an integer from 1-4. The process of the invention is useful for preparation of alpha-arylated or vinylated carbonyl-containing compounds which are significant in the development of pharmacologically active compounds and polymers and oligomers.

REFERENCES:
Ozawa, fumuyuki et al., Palladium-Catalyzed Double Carbonylation of Aryl Halides Affording alpha-keto Amides. (1986), 51, pp415-417.

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