Organic compounds -- part of the class 532-570 series – Organic compounds – Fatty compounds having an acid moiety which contains the...
Patent
1995-06-07
1998-09-01
Geist, Gary
Organic compounds -- part of the class 532-570 series
Organic compounds
Fatty compounds having an acid moiety which contains the...
584 78, 584 79, 584 82, 584101, 584102, 584114, 568 61, 568 62, 568 63, 568579, 568583, 568589, 568700, 568704, 568852, C07F 902
Patent
active
058012605
ABSTRACT:
Novel substrates of phospholipases, lysophospholipases and lipases are disclosed.
REFERENCES:
patent: 5277508 (1994-01-01), Kozikowski et al.
Dennis, E.A., "Phospholipases" The Enzymes 1983, 3rd. Ed., Academic Press, New York, 16, 307-353.
Irvine, R.F., "How is the level of free arachidonic acid controlled in mammalian cells?" Biochem J. 1982, 204, 3-16.
Snyder, F., "Chemical and biochemical aspects of platelet activating factor: A novel class of acetylated ether-linked choline-phospholipids" Med. Res. Rev. 1985, 5, 107-140.
Pruzanski, W. & Vadas, P., "Phospholipase A.sub.2 --a mediator between proximal and distal effectors of inflammation" Immunology Today 1991, 12, 143-146.
Vadas, P. & Pruzanski, W., "Biology of disease: Role of secretory phospholipases A.sub.2 in the pathobiology of disease" Lab. Invest. 1986, 55, 391-404.
Nevalainen, T.J., "Serum phospholipases A.sub.2 in inflammatory diseases" Clin. Chem. 1993, 39, 2453-2459.
Green, J.-A., et al., "Circulating phospholipase A.sub.2 activity associated with sepsis and septic shock is indistinguishable from that associated with rheumatoid arthritis" Inflammation, 1991, 15, 355-367.
Vadas, P., et al., "Serum phospholipase A.sub.2 enzyme activity and immunoreactivity in a prospective analysis of patients with septic shock" Life Sci. 1992, 50, 807-811.
Nevalainen, T.J., "Phospholipase A.sub.2 in acute pancreatitis" Scand. J. Gastroenterol. 1988, 23, 897-904.
Smith, G.M., et al., "Measurement of human phospholipase A.sub.2 in arthritis plasma using a newly developed sandwich ELISA" British J. Rheumatology 1992, 31, 175-178.
Dole, V.P., "A relation between non-esterified fatty acids in plasma and the metabolism of glucose" J. Clin. Invest. 1956, 35, 150-154.
van den Bosch, H., et al., "Phospholipase A.sub.2 from rat liver mitochondria" Methods Enzymol. 1991, 197, 365-373.
Lister, M.D., et al., "Kinetic analysis of the CA.sup.2+ -dependent, membrane-bound, macrophage phospholipase A.sub.2 and the effects of arachidonic acid" J. Biol. Chem. 1988, 263, 7506-7513.
Kramer, R.M. & Pepinsky, R.B., "Assay and purification of phospholipase A.sub.2 from human synovial fluid in rheumatoid arthritis" Methods Enzymol. 1991, 197, 373-381.
Yu, L. & Dennis, E.A., "Thio-based phospholipase assay" Methods Enzymol. 1991, 197, 65-75.
Reynolds, L.J., et al., "Analysis of human synovial fluid phospholipase A.sub.2 on short chain phosphatidylcholine-mixed micelles: Development of a spectrophotometric assay suitable for a microtiterplate reader" Anal. Biochem. 1992, 204, 190-197.
Reynolds, L.J., et al., "1-hexadecyl-2-arachidonoylthio-2-deoxy-sn-glycero-3-phosphorylcholine as a substrate for the microtiterplate assay of human cytosolic phospholipase A.sub.2 " Anal. Biochem. 1994, 217, 25-32.
Hendrickson, H.S., et al., "Synthesis of a naphthylvinyl-labeled glycerol ether analog of phosphatidylcholine and its use in the assay of phospholipase A.sub.2 " J. Lipid Res. 1987, 28, 864-872.
Radvanyi, F., et al., "A sensitive and continuous fluorometric assay for phospholipase A.sub.2 using pyrene-labeled phospholipids in the presence of serum albumin" Anal. Biochem. 1989, 177, 103-109.
Hendrickson, H.S., "Fluorescence-based assays of lipases, phospholipases, and other lipolytic enzymes" Anal. Biochem. 1994, 219, 1-8.
Hendrickson, H.S. & Hendrickson, E.K., "A facile asymmetric synthesis of glycerol phospholipids via tritylglycidol prepared by the asymmetric epoxidation of allyl alcohol. Thiolester and thioether analogs of phosphatidylcholine" Chem. Phys. Lipids 1990, 53, 115-120.
Satouchi, K., et al., "Evidence for production of 1-acyl-2-acetyl-sn-glyceryl-3-phosphorylcholine concomitantly with platelet-activating factor" Biochem. Biophys. Res. Comm. 1985, 128, 1409-1417.
Washburn, W.N. & Dennis, E.A., "Suicide-inhibitory bifunctionally linked substrates (SIBLINKS) as phospholipase A.sub.2 inhibitors" J. Biol. Chem. 1991, 266, 5042-5048.
Tegeler et al., "Hydroxy-, alkoxy-, and benzyloxy-substituted phospholipids, a process for their preparation, their pharmaceutical compositions, and their use as phospholipase A2 inhibitors" Chem. Abstracts (1989) 111(5):576 (abstract No. 39106z).
Campbell et al., "Synthesis of structural variants of phospholipids: inhibition of phospholipase A2" Chem. Abstracts (1990) 112(15):781 (abstract No. 39698h).
Termansky Robert John
Yu Lin
Carr Deborah D.
Geist Gary
LaJolla Pharmaceuticals Co.
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