Carbonate Intermediates useful in the preparation of optically a

Details Carbonate Intermediates useful in the preparation of optically a Carbonate Intermediates useful in the preparation of optically a

1998-10-22

1999-10-26

Ambrose, Michael G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbonate esters

558275, C07C 6996

Patent

active

059731826

ABSTRACT:
A process for the preparation of optically active phenylcyclohexylglycolate esters is described. The process utilizes carboxylic acid activation to couple (R)- or (S)-cyclohexylphenylglycolic acid (CHPGA) with 4-N,N-diethylamino butynol or other propargyl alcohol derivatives. The preparation of the hydrochloride salt is also described. In addition, a resolution process employing tyrosine methyl ester enantiomers for preparing a single enantiomer of CHPGA from racemic CHPGA is disclosed.

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