Carbonate intermediates for the synthesis of purine substituted

Details Carbonate intermediates for the synthesis of purine substituted Carbonate intermediates for the synthesis of purine substituted

1991-11-06

1993-08-31

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D47318, C07D47340

Patent

active

052410692

ABSTRACT:
This invention relates to the new process for preparing the 1R-cis isomer of carbovir, (1R-cis)-amino-1,9-dihydro-9-[4-(hydroxymethyl)-2-cyclopenten-1-yl]-6H-pur in-6-one, an antiviral agent and intermediates of the formula (Vlb) use in that process ##STR1## wherein X is chloro, bromo or iodo and R is (C.sub.1-6) alkyl.

REFERENCES:
patent: 4916224 (1990-04-01), Vince et al.
patent: 5057630 (1991-10-01), Lackey
patent: 5126452 (1992-06-01), Vince
March, J., Advanced Organic Chemistry, 3rd Ed., Chap. 4 John Wiley & Sons, New York, N.Y.(1985).
Vince, R., et al., Biochem. Biophys. Res. Commun. 156 (2) 1045 (1988).
J. Am. Chem. Soc., 110, 621 (1988).
Synthesis, Sugai, T., et al., 19-22 (1988).
J.C.S. Perkin I, Bajorek, R., 1, 1243 (1974).

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