Carbon monoxide dependent guanyly cyclase modifiers and methods

Details Carbon monoxide dependent guanyly cyclase modifiers and methods Carbon monoxide dependent guanyly cyclase modifiers and methods

1998-05-29

2000-02-22

Park, Hankyel

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

514 45, 514310, 514262, 544265, 544276, 435 721, C12N 500, A01N 4304, A01N 4342, A01N 4390, C07D47300

Patent

active

060279362

ABSTRACT:
Disclosed herein are methods directed generally to the control of neural activity and for selectively and controllably inducing the in vivo genetic expression of one or more naturally occurring genetically encoded molecules in mammals. More particularly, the present invention selectively activates or derepresses genes encoding for specific naturally occurring molecules such as neurotrophic factors through the administration of carbon monoxide dependent guanylyl cyclase modulating purine derivatives. The methods of the present invention may be used to affect a variety of cellular and neurological activities and to therapeutically or prophylactically treat a wide variety of neurodegenerative, neurological, and cellular disorders.

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