Carbohydrate-specific peptides which have a strong affinity...

Details Carbohydrate-specific peptides which have a strong affinity... Carbohydrate-specific peptides which have a strong affinity...

2006-09-05

2006-09-05

Campell, Bruce R. (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S300000

Reexamination Certificate

active

07101841

ABSTRACT:
The present invention relates to carbohydrate-specific peptides, which have a strong affinity and preparation method thereof. Particularly, the present invention relates to carbohydrate-specific peptides, which have been developed to have an increased strong affinity to carbohydrates by the multiple combinations of peptides having carbohydrates-specific amino acid sequences and preparation method thereof. Carbohydrate-specific peptides of the present invention have a very strong affinity under micromol, so that they can shut off recognition between cells transferred by specific carbohydrates, which means they can be used for the treatment of diseases mediated by recognition between cells and used as a diagnostic kit which diagnoses diseases by confirming the existence of any specific carbohydrate.

REFERENCES:
patent: WO 94/07517 (1994-04-01), None
Tam, JP., 1996, J. Immunol. Methods, 196, 17-32.
Tam, JP., Journal Immunological Methods, 1996, 196, 17-32.
Ravindranath, et al., Cancer, 1997, 79, 1686-1697.
Dean, JW, The Journal of Biological Chemistry, 1990, 265, 12553-12562.
An article entitled “Generation of C-Glycoside Peptide Ligands for Cell Surface Carbohydrate . . . ,” By Sutherlin et al., published by J. Org. Chem. 1996, vol. 61, pp. 8350-8354.

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