Carbohydrate receptor for bacteria and method for use thereof

Details Carbohydrate receptor for bacteria and method for use thereof Carbohydrate receptor for bacteria and method for use thereof

1988-08-01

1993-06-08

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

536 53, 5361231, 514 54, 4352533, 4352534, 435851, 435874, 435882, 435885, G01N 3353, A61K 3170

Patent

active

052177157

ABSTRACT:
The invention is a carbohydrate receptor for pathogenic bacteria. The receptor is a purified carbohydrate compound that is a member selected from the group consisting of fucosyl-asialo GM1, asialo GM1, and asialo GM2. The invented receptor can be included in a composition having a pharmaceutically acceptable carrier. The invention includes methods for purifying, detecting, or removing bacteria from diseased tissue. The applicants have discovered a carbohydrate receptor for a variety of different species of disease-producing bacteria. The structure of the receptor is N-acetylgalactosamine-beta-1-4-galactose-beta-1-4-glucose, abreviated GalNAc.beta.1-4Gal.beta.1-4Glc. The receptor is present in human and animal tissues as complex molecules and can serve as the attachment site for bacterial infection. For example, fucosyl-asialo GM1, asialo GM1, and asialo GM2 are three biological molecules which occur in cell membranes and contain the carbohydrate receptor.

REFERENCES:
patent: 4657849 (1987-04-01), Kallenius et al.
patent: 4725557 (1988-02-01), Miyauchi et al.

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