Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1993-01-13
1995-02-14
Bidwell, Carol E.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 732, 435 734, 436518, 436534, G01N 33569
Patent
active
053895215
ABSTRACT:
The invention is a method for detecting pathogenic bacteria by specific binding of the bacteria to GalNAc.beta.1-4Gal sequences found in fucosyl-asialo GM1, asialo GM1 and asialo GM2. An agglutination reaction is disclosed comprising contacting a culture suspected of containing the bacteria with a suspension of a purified carbohydrate compound bound to an insoluble carrier and detecting the presence of perceptible agglutination of the carrier as an indication of the presence of the bacteria. Bacteria which can be detected using the claimed method include Pseudomonas, Haemophilus, Staphylococcus, Klebsiella and Streptococcus pneumoniae.
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Stromberg et al. "Identification of carbohydrate structures that are possible receptors of Neisseria gonorrhoeae", Proc. Natl. Acad. Sci. USA, 85(13):4902-4906 (Jul. 1988).
DeMan et al. "Receptor-Specific Agglutination Tests for Detection of Bacteria that Bind Globoseries Glycolpids", J. Clin. Microbiol., 25(2):401-406 (FEb. 1987).
Ginsburg Victor
Krivan Howard C.
Roberts David D.
Bidwell Carol E.
The United States of America as represented by the Department of
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