Carbohydrate perturbations of viruses or viral antigens and util

Details Carbohydrate perturbations of viruses or viral antigens and util Carbohydrate perturbations of viruses or viral antigens and util

1986-11-18

1989-08-01

Warden, Robert J.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 7, 436507, 436510, 436511, 436518, 436543, 436548, 436812, 436820, G01N 33531, G01N 33569, G01N 33571, G01N 33576

Patent

active

048533262

ABSTRACT:
Novel and improved methods for diagnosis, prognosis, prophylaxis and therapy of viral infections are described. The novel methods employ a virus, viral antigen or fragment thereof in which "perturbation" of an oligosaccharide moiety renders the virus, viral antigen or fragment thereof more specifically recognizable or reactive with neutralizing antibody. As described, "perturbation" of an oligosaccharide moiety encompasses any modification that (1) alters the chemical or physical structure of a carbohydrate residue that is naturally present; (2) that removes, wholly or in part, a carbohydrate residue; and/or (3) that prevents or alters addition of a carbohydrate residue. A variety of methods for oligosaccharide "perpetuation" are also described.

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